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KMID : 1141520210360020322
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Endocrinology and Metabolism
2021 Volume.36 No. 2 p.322 ~ p.338
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Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force
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Ku Eu-Jeong
Kim Kyoung-Jin
Kim Jung-Hee
Kim Mi-Kyung
Ahn Chang-Ho
Lee Kyung-Ae
Lee Seung-Hun
Lee You-Bin
Park Kyeong-Hye
Choi Yun-Mi
Hong Nam-Ki
Hong A-Ram
Kang Sang-Wook
Park Byung-Kwan
Seong Moon-Woo
Kim Myung-Shin
Jung Kyeong-Cheon
Jung Chan-Kwon
Cho Young-Seok
Paeng Jin-Chul
Kim Jae-Hyeon
Ryu Ohk-Hyun
Rhee Yu-Mie
Kim Chong-Hwa
Lee Eun-Jig
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Abstract
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Pheochromocytoma and paraganglioma (PPGLs) are rare catecholamine-secreting neuroendocrine tumors but can be life-threatening. Although most PPGLs are benign, approximately 10% have metastatic potential. Approximately 40% cases are reported as harboring germline mutations. Therefore, timely and accurate diagnosis of PPGLs is crucial. For more than 130 years, clinical, molecular, biochemical, radiological, and pathological investigations have been rapidly advanced in the field of PPGLs. However, performing diagnostic studies to localize lesions and detect metastatic potential can be still challenging and complicated. Furthermore, great progress on genetics has shifted the paradigm of genetic testing of PPGLs. The Korean PPGL task force team consisting of the Korean Endocrine Society, the Korean Surgical Society, the Korean Society of Nuclear Medicine, the Korean Society of Pathologists, and the Korean Society of Laboratory Medicine has developed this position statement focusing on the comprehensive and updated diagnosis for PPGLs.
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KEYWORD
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Pheochromocytoma, Paraganglioma, Diagnosis, Classification
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